The mN1A monoclonal antibody reacts with the intracellular domain of human and mouse Notch1 with high affinity for the activated intracellular form and lower affinity for the full length heterodimeric Notch1 forms.
It does not react with Notch2,3, or 4 and does not cross-react with rat thymocytes.
The neurogenic locus homolog protein 1 （Notch1） is a trasmembrane receptor that regulates cell fate decisions.
It is expressed in CD4-CD8- and CD4-CD8+ thymocytes, and plays a role in the regulation of myelopoiesis and lymphopoiesis.
