84-7737-25　Anti-Human/Mouse CD45R (B220) BG Violet 450 25ug　07131-40-25

仕様

• サイズ：25ug
• The RA3-6B2 monoclonal antibody specifically reacts with a 220 kDa exon A-restricted epitope on the extracellular domain of mouse CD45 glycoprotein.
• CD45R/B220 is expressed on all the development stages of B cells, and at a low level on plasma cells and a subset of memory B cells.
• Low levels of CD45R/B220 are also expressed by some activated T lymphocytes, natural killer cell progenitors in the bone marrow, lymphokine activated killer cells （LAK）, T lymphocytes of lpr/lpr mutant mouse, apoptotic T cells of mice injected with bacterial superantigens, and macrophage progenitors in fetal liver.
• The CD45 molecule is a member of the Protein Tyrosine Phosphatase （PTP） family, because its intracellular region contains two PTP domains.
• The extracellular region's variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons.
• The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction.
• The RA3-6B2 antibody inhibits in vivo B lymphocytes responses and enhances isotype switching during in vitro B lymphocyte responses.
• BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes.
• It is excited by the violet （405 nm） laser, with a peak emission of 450nm.
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