84-7735-41　Anti-Human CD80 (B7-1) PE 100 tests　02911-60-100

仕様

• サイズ：100 tests
• The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 （CTLA-4） and for CD28, a co-stimulatory receptor for the T cell receptor （TCR）.
• CD28 also binds a second B7 ligand known as CD86 （B7-2）.
• Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells.
• These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity.
• The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
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