The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 （TLR4）.
CD284 is an important molecule in the innate immunity response to bacterial lipoproteins.
It is expressed by monocytes, macrophages, and endothelial cells.
The HTA125 antibody can block Lipopolysaccharide-induced cytokine production and immunoprecipitate human TLR4.
