The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes.
CD28 is a ligand for B7-1 （CD80） and B7-2 （CD86）, a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes.
It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some subregions with distinct functions.
The CD28.
2 antibody induces Ca2+ influx in Jurkat T lymphocytes.
Other studies have shown that CD28 is involved in the signal transduction.
