84-6253-32　SARS-CoV-2 (COVID-19) Alpha Variant (B.1.1.7, UK) Spike P681H 100ug　583257

特徴

• In September of 2020 a new lineage of SARS-CoV-2, known as B.1.1.7, was discovered in the United Kingdom.
• This lineage was found to have developed 14 lineage-specific amino acid replacements and 3 deletions prior to its discovery.
• The transmission of UK variant (B.1.1.7 lineage) was increased at least 50%.
• Increased severity and higher death rate were also found in UK variant.
• UK variant will not affect the effectiveness of COVID19 vaccine.
• One of the mutations associated with this lineage is a N501Y in the spike protein of the virus.
• It is believed that this mutation is able to increase the spike protein's affinity for the host ACE2 receptor and it has been associated with increased infectivity and virulence.
• B.1.1.7 viruses have also been shown to have a P681H in the cleavage site of spike protein.
• This location is one of the residues that make up the furin cleavage site between S1 and S2 in spike protein.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.