84-6252-97　IRF7 100ug　583193

特徴

• Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms.
• During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes.
• IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes.
• IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling.
• There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.
• Applications:Suitable for use in ELISA, Immunohistochemistry, Immunofluorescence and Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.5-1ug/mlImmunofluorescence: 20ug/mlImmunohistochemistry (paraffin): 20ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:A549 Cell Lysate, HeLa Cell Lysate, HepG2 Cell Lysate
• Molecular Weight:~17kD (predicted), 17kD (observed)
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.