84-6252-71　CD276 100ug　583157

特徴

• CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 molecules.
• CD276 mRNA is widely expressed, but its protein expression is usually rather low.
• CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response.
• In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity.
• It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers.
• Applications:Suitable for use in ELISA, Immunohistochemistry, Immunofluorescence and Western Blot.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 0.5-1ug/mlImmunohistochemistry (Paraffin): 2ug/mlImmunofluorescence: 20ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Human spleen tissue lysate, Mouse spleen tissue lysate
• Molecular Weight:~35kD, 43kD, 57kD (predicted), 59kD (observed)
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.