The proto-oncogene Bcl-3, believed to be involved in certain human B cell leukemias, encodes a protein that contributes to the regulation of transcriptional activation of NF-kappa-B target genes.
BCL3 contains seven ankyrin repeats, which are most closely related to those found in I-kappa-B proteins.
The expression of this gene can be induced by NF-kappa-B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa-B.
It contributes to the regulation of cell proliferation.
A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:HEK293 Cell Lysate
Molecular Weight:~50kD (predicted)
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human BCL3.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to 17aa, aa360-410, near the C-terminus of human BCL3.
