Angiogenin (ANG or ANG I) is important for the process of neovascularization and formation of new blood vessels.
ANG is similar to pancreatic ribonuclease A and functions as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs.
It interacts with endothelial cell-surface actin and may cause changes in the cell cytoskeleton.
ANG is thought to be involved in the development of solid tumors and its antagonists are capable of inhibiting tumor growth.
Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9).
Angiogenin is a genetic link between ALS and PD.
Applications:Suitable for use in ELISA, Immunofluorescence and Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1-2ug/mlImmunofluorescence: 20ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Rat Liver Tissue Lysate, Human Liver Tissue Slide
Molecular Weight:~16kD
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human ANG. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IF WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to 15 amino acids, aa70-120, near the center of human ANG. Species sequence homology: equine: (75%)
