84-6252-43　TNIK (S764) 200ul　378670

特徴

• Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway.
• Recruited to promoters of Wnt target genes and required to activate their expression.
• May act by phosphorylating TCF4/TCF7L2.
• Appears to act upstream of the JUN N-terminal pathway.
• May play a role in the response to environmental stress.
• Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development.
• More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading.
• Phosphorylates SMAD1 on Thr-322.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500Immunohistochemistry (paraffin): 1:500Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.