Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors.
May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes.
Activated by IL31 through IL31RA.
Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.
Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
Applications:Suitable for use in Western Blot and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500Immunofluorescence: 1:25Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A and peptide affinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human STAT3. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：IF WB
Calc Crossreactivity：Hu Mo
Immunogen：KLH-conjugated synthetic peptide mapping to a fragment of residues within aa710-740 from human STAT3.
