84-6251-74 POLH, NT 200ul 378590
特徴
- DNA polymerase specifically involved in DNA repair.
- Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls.
- Plays an important role in the repair of UV-induced pyrimidine dimers.
- Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions.
- May play a role in hypermutation at immunoglobulin genes.
- Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
- Targets POLI to replication foci.
- Applications:Suitable for use in Western Blot.
- Other applications not tested.
- Recommended Dilution:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for 12 months after receipt.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：200ul
- Host：rabbit
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by Protein A and peptide affinity chromatography.
- Form：Supplied as a liquid in PBS, 0.09% sodium azide.
- Specificity：Recognizes human POLH.
- Isotype：IgG
- Calc Applications Abbrev：WB
- Calc Crossreactivity：Hu
- Immunogen：KLH-conjugated synthetic peptide mapping to a fragment of residues within aa68-92 from human POLH. Species sequence homology: mouse
- Shelf Life：1year
- Swiss Prot Number：Q9Y253
- EU Commodity Code：30021010
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