Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways.
Binds to, and suppresses signals from, the activated insulin receptor (INSR).
Potent inhibitor of insulin-stimulated MAPK3 phosphorylation.
Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Applications:Suitable for use in Western Blot, Indirect Flow Cytometry and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000Indirect Flow Cytometry: 1:25Immunofluorescence: 1:25Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A and peptide affinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human GRB14.
Isotype：IgG
Calc Applications Abbrev：FC IF WB
Calc Crossreactivity：Hu
Immunogen：KLH-conjugated synthetic peptide mapping to a fragment of residues within aa14-48 from human GRB14 at N-terminal.
