Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR).
Required for cardiacmyogenesis and hepatogenesis during embryonic development, and thedevelopment of secretory tissues such as exocrine pancreas and salivary gland (By similarity).
Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154).
Modulates the cellular response to ER stress in a PIK3R-dependent manner(PubMed:20348923).
Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596).
Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions.
Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for themanagement of obesity and diabetes prevention (By similarity).
Applications:Suitable for use in ELISA, Immunohistochemistry and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human XBP1.
Isotype：IgG
Calc Applications Abbrev：E IF IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa1-167 from human X-box-binding protein 1 protein.
