84-6232-16 WT1 100ug 581652
特徴
- Transcription factor that plays an important role in cellular development and cell survival.
- Regulates the expression of numerous target genes, including EPO.
- Plays an essential role for development of the urogenital system.
- Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'.
- It has a tumor suppressor as well as an oncogenic role in tumor formation.
- Function may be isoformspecific: isoforms lacking the KTS motif may act as transcription factors.
- Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing.
- Isoform 1 has lower affinity for DNA, and can bind RNA.
- Applications:Suitable for use in ELISA and Immunohistochemistry.
- Other applications not tested.
- Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for 12 months after receipt.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：100ug
- Host：rabbit
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by Protein G affinity chromatography.
- Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
- Specificity：Recognizes human WT1.
- Isotype：IgG
- Calc Applications Abbrev：E IHC
- Calc Crossreactivity：Hu
- Immunogen：Recombinant protein corresponding to aa1-449 from human Wilms tumor protein.
- Shelf Life：1year
- Swiss Prot Number：P19544
- EU Commodity Code：30021010
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