84-6229-16　WDR83 50ul　581504

特徴

• Molecular scaffold protein for various multimeric protein complexes.
• Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists.
• At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation.
• Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3.
• May promote degradation of HIF1A.
• May act by recruiting signaling complexes to a specific upstream activator (By similarity).
• May also be involved in pre-mRNA splicing.
• Applications:Suitable for use in ELISA, Immunohistochemistry and Immunofluorescence.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:200-1:500Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.