84-6224-55　VPS29 50ug　581276

特徴

• Acts as component of the retromer cargo-selective complex (CSC).
• The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
• The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.
• The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling.
• The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway.
• The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins.
• The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5.
• Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (Probable).
• Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunofluorescence.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:5000Immunohistochemistry: 1:20-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.