84-6224-49　［取扱停止］VPS26B (Biotin) 50ug　581273

特徴

• Acts as component of the retromer cargo-selective complex (CSC).
• The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
• The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.
• The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling.
• The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway.
• The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins.
• The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5.
• May be involved in retrograde transport of SORT1 but not of IGF2R.
• Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.