84-6203-28　TSPAN12 50ug　580223

特徴

• Regulator of cell surface receptor signal transduction.
• Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction.
• Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs.
• Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity).
• Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP.
• Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP).
• Activates MMP14/MT1-MMP-dependent cleavage activity.
• Applications:Suitable for use in ELISA, Immunohistochemistry and Immunofluorescence.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:200-1:500Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.