84-6201-41　TRPV1 100ug　580130

特徴

• Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli.
• Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons.
• Involved in mediation of inflammatory pain and hyperalgesia.
• Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.
• Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state.
• Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel.
• Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin.
• Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects.
• Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.
• Applications:Suitable for use in ELISA, Immunohistochemistry and Immunofluorescence.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:20-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.