Plays a key role in chromosome recombination and chromosome structure development during meiosis.
Required at early steps in meiotic recombination that leads to non-crossovers pathways.
Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways.
Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation.
In males, required for efficient synapsis of the sex chromosomes and for sex body formation.
Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes.
Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity).
Plays a role in mitotic spindle assembly checkpoint (SAC) activation.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human TRIP13.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa181-390 from human Pachytene checkpoint protein 2 homolog protein.
