84-6200-29　TRIP10 (HRP) 50ug　580075

特徴

• Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity).
• Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis.
• Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules.
• Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex.
• Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles.
• Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells.
• May be required for the lysosomal retention of FASLG/FASL.
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.