84-6195-79　TRAF3 (FITC) 100ug　579852

特徴

• Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival.
• Part of signaling pathways leading to the production of cytokines and interferon.
• Required for normal antibody isotype switching from IgM to IgG.
• Plays a role T-cell dependent immune responses.
• Plays a role in the regulation of antiviral responses.
• Is an essential constituent of several E3 ubiquitin-protein ligase complexes.
• May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins.
• Inhibits activation of NF-kappa-B in response to LTBR stimulation.
• Inhibits TRAF2-mediated activation of NF-kappa-B.
• Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B.
• Promotes ubiquitination and proteasomal degradation of MAP3K14.
• Applications:Suitable for use in FLISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: FITC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.