Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus.
Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.
May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity.
In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity.
May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence.
May have a zinc-dependent DNA-binding activity.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-2000ELISA: 1:10,000-20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human TGFB1I1. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa291-340 from human Hic-5.
