Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly.
Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB).
Its ability to interact with beta tubulin is regulated via its interaction with ARL2.
Acts as a GTPase-activating protein (GAP) for ARL2.
Induces microtubule disruption in absence of ARL2.
Increases degradation of beta tubulin, when overexpressed in polarized cells.
Promotes epithelial cell detachment, a process antagonized by ARL2.
Induces tight adherens and tight junctions disassembly at the lateral cell membrane.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with Biotin.
Specificity：Recognizes human TBCD.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa2-96 from human tubulin-specific chaperone D.
