84-6155-85　SSRP1 (FITC) 100ug　577875

特徴

• Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes.
• The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair.
• During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure.
• It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
• The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).
• Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin.
• May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA.
• Also acts as a transcriptional coactivator for p63/TP63.
• Applications:Suitable for use in FLISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: FITC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.