Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases.
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis.
Binds the receptor-associated protein (RAP).
Could play a role in cell-cell interaction.
Involved in APP trafficking to and from the Golgi apparatus.
It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation.
Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with Biotin.
Specificity：Recognizes human SORL1.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa525-744 from human sortilin-related receptor.
