Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases.
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis.
Binds the receptor-associated protein (RAP).
Could play a role in cell-cell interaction.
Involved in APP trafficking to and from the Golgi apparatus.
It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation.
Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human SORL1.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa525-744 from human Sortilin-related receptor protein.
