Involved in endocytosis and intracellular vesicle trafficking, both duringinterphase and at the end of mitosis.
Required for efficient progress through mitosis and cytokinesis.
Required for normal formation of the cleavage furrow at the end of mitosis.
Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis.
Plays a role in macropinocytosis.
Promotes internalization of TNFR.
Promotes degradation of EGFR after EGF signaling.
Stimulates the GTPase activity of DNM1.
Promotes DNM1 oligomerization.
Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton.
Bindsto membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation.
Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:5000Immunohistochemistry: 1:20-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human SNX9.
Isotype：IgG
Calc Applications Abbrev：E IF IHC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa85-200 from human sorting nexin-9 protein.
