Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment.
Contributes to axial element (AE) formation and the organization of chromatin loops along the AE.
Plays a key role in synapsis, recombination and chromosome movements.
The cohesin complex is required for the cohesion of sister chromatids after DNA replication.
The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped.
At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with Biotin.
Specificity：Recognizes human SMC1B.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa954-1060 from human structural maintenance of chromosomes protein 1B.
