Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment.
Contributes to axial element (AE) formation and the organization of chromatin loops along the AE.
Plays a key role in synapsis, recombination and chromosome movements.
The cohesin complex is required for the cohesion of sister chromatids after DNA replication.
The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped.
At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:200-1:500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human SMC1B.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa954-1060 from human structural maintenance of chromosomes protein 1B.
