84-6122-73　SH3GLB1 50ug　576236

特徴

• May be required for normal outer mitochondrial membrane dynamics(PubMed:15452144).
• Required for coatomer-mediated retrograde transport in certain cells.
• May recruit other proteins to membranes with high curvature.
• May promote membrane fusion (PubMed:11604418).
• Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588).
• Isoform 1 acts proapoptotic in fibroblasts.
• Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy.
• Activates lipid kinase activity of PIK3C3 duringautophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140).
• Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542).
• Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context ofPI3KC3-C2 (PubMed:20643123).
• Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability.
• Applications:Suitable for use in ELISA and Immunofluorescence.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.