84-6116-71　SEMA4D (HRP) 50ug　575937

特徴

• Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling.
• Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system.
• Regulates dendrite and axon branching and morphogenesis.
• Promotes the migration of cerebellar granule cells and of endothelial cells.
• Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro).
• Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade.
• Interaction with PLXNB1 mediates activation of RHOA.
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.