84-6099-33　RORB (Biotin) 100ul　575076

特徴

• Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence.
• Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity.
• Required for normal postnatal development of rod and cone photoreceptor cells.
• Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway.
• In cone photoreceptor cells, regulates transcription of OPN1SW.
• Involved in the regulation of the period length and stability of the circadian rhythm.
• May control cytoarchitectural patterning of neocortical neurons during development.
• May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons.
• May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.