RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation.
Modulates alternative 5'-splice site and exon selection.
Acts as a muscle cell differentiation-promoting factor.
Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation.
Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin.
Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs.
Required for the translational activation of PER1 mRNA in response to circadian clock.
Binds directly to the 3'-UTR of the PER1 mRNA.
Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation.
Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress.
Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions.
Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs.
Associates with miRNAs during muscle cell differentiation.
Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro.
Applications:Suitable for use in FLISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: FITC conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with Fluorescein isothiocyanate (FITC).
Specificity：Recognizes human RBM4.
Isotype：IgG
Calc Applications Abbrev：FLISA
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa121-205 from human RNA-binding protein 4 protein.
