Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation.
Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression.
Controls histone H4 'Lys-20' trimethylation.
Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters.
Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5.
Binds to cyclins A and E.
Binds to and may be involved in the transforming capacity of the adenovirus E1A protein.
May act as a tumor suppressor.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:200-1:500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human RBL2.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa417-616 from human retinoblastoma-like protein 2.
