Plays a role as a modulator of TGF-beta-signaling by restricting substratespecificity of RNF111.
Involved in autophagy.
Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1.
Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy.
Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis.
Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).
Implicated in the regulation of RB1 expression.
Functions as a DNA-binding transcription factor.
Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation.
Expression is, thus, a prerequisite for myogenic differentiation.
Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways.
Applications:Suitable for use in ELISA and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human RB1CC1.
Isotype：IgG
Calc Applications Abbrev：E IF
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa1544-1594 from human RB1-inducible coiled-coil protein 1 protein.
