Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotideexchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768).
Activates the Erk/MAP kinase cascade (PubMed:15899849).
Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994).
Regulates NK cellcytotoxicity and ITAM-dependent cytokine production by activation of Rasmediated ERK and JNK pathways (PubMed:19933860).
Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity).
May also function in differentiation of other cell types (PubMed:12845332).
Applications:Suitable for use in ELISA and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human RASGRP1.
Isotype：IgG
Calc Applications Abbrev：E IF
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa594-716 from human RAS guanyl-releasing protein 1 protein.
