Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development.
Required for normal alternative splicing of target pre-mRNA species (PubMed:23512658).
May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner.
Can activate transcription directly or via association with the transcription machinery.
May be involved in ATXN1 mutant-induced cell death.
The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human PQBP1.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa2-265 from human polyglutamine-binding protein 1 protein.
