Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins.
Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1.
Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.
Applications:Suitable for use in ELISA, Immunohistochemistry and Immunofluorescence.