84-6050-41　PLXNB2 50ul　572655

特徴

• Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays animportant role in cell-cell signaling.
• Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'.
• Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development.
• Regulates the migration of cerebellar granule cells in the developing brain.
• Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton.
• Plays a role in axon guidance, invasive growth and cell migration.
• May modulate the activity of RAC1 and CDC42.
• Down-regulates macrophage migration in woundhealing assays (in vitro) (By similarity).
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1;500-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.