84-6040-76　PIF1 100ug　572177

特徴

• DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
• Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids.
• Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs.
• Involved in the maintenance of telomeric DNA.
• Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase.
• Reduces the processivity of telomerase by displacing active telomerase from DNA ends.
• Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction.
• Possesses an intrinsic strand annealing activity.
• Applications:Suitable for use in ELISA and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.