84-6033-63　PDK4 100ug　571824

特徴

• Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2.
• This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate.
• Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation.
• Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade.
• Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation.
• In the fed state, mediates cellular responses to glucose levels and to a high-fat diet.
• Regulates both fatty acid oxidation and de novo fatty acid biosynthesis.
• Plays a role in the generation of reactive oxygen species.
• Protects detached epithelial cells against anoikis.
• Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
• Applications:Suitable for use in ELISA and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:20-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.