Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes.
Plays a role in early development.
In DNA damage response is required for cell survival after ionizing radiation.
In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs).
Its localization to DNA damage foci requires RNF8 and UBE2N.
Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'.
Together with TP53BP1 regulates ATM association.
Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with Biotin.
Specificity：Recognizes human PAXIP1.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa613-812 from human PAX-interacting protein 1.
