84-6022-99　PA2G4 (Biotin) 50ug　571298

特徴

• May play a role in a ERBB3-regulated signal transduction pathway.
• Seems be involved in growth regulation.
• Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG).
• Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity.
• Binds RNA.
• Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA.
• May be involved in regulation of intermediate and late steps of rRNA processing.
• May be involved in ribosome assembly.
• Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity).
• Regulates cell proliferation, differentiation, and survival.
• Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.