This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds.
At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell.
May therefore cause structural modifications of exofacial proteins.
Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins.
At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins.
At low concentrations, facilitates aggregation (anti-chaperone activity).
May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis.
Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.
Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：Cricetulus griseus
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes cricetulus griseus P4HB.
Isotype：IgG
Calc Applications Abbrev：E
Immunogen：Recombinant protein corresponding to aa20-509 from cricetulus griseus protein disulfide-isomerase protein.
