Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination.
Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Affects the implementation of differentiation, proliferation and apoptotic programs.
Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.
Involved in the maturation of both CD4+ and CD8+ cells in the thymus.
Important for follicular differentiation and possibly cell fate selection within the follicle.
During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.
Represses neuronal and myogenic differentiation.
May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation.
May be involved in mesoderm development, somite formation and neurogenesis.
May enhance HIF1A function by sequestering HIF1AN away from HIF1A.
Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury.
Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with Biotin.
Specificity：Recognizes human NOTCH1.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa2428-2555 from human neurogenic locus notch homolog protein 1.
