Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination.
Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Affects the implementation of differentiation, proliferation and apoptotic programs.
Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.
Involved in the maturation of both CD4+ and CD8+ cells in the thymus.
Important for follicular differentiation and possibly cell fate selection within the follicle.
During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.
Represses neuronal and myogenic differentiation.
May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation.
May be involved in mesoderm development, somite formation and neurogenesis.
May enhance HIF1A function by sequestering HIF1AN away from HIF1A.
Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury.
Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
Applications:Suitable for use in ELISA, Immunohistochemistry and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 1:20-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Specificity：Recognizes human NOTCH1.
Isotype：IgG
Calc Applications Abbrev：E IF IHC
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to aa2428-2555 from human Neurogenic locus notch homolog protein 1.
