84-5999-28　NGEF 50ul　570124

特徴

• Acts as a guanine nucleotide exchange factor (GEF) which differentiallyactivates the GTPases RHOA, RAC1 and CDC42.
• Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis.
• Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation.
• Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
• Applications:Suitable for use in ELISA and Immunofluorescence.
• Other applications not tested.
• Recommended Dilutions:Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.